C-X-C motif ligand 13 (CXCL13)

Authors
Affiliations

Nathaniel Yomogida, B.S., SPT

Doctor of Physical Therapy

B.S. in Kinesiology

Chloë Kerstein, B.S., SPT

Doctor of Physical Therapy

B.A. in Neuroscience

a key homeostatic chemokine constitutively expressed in lymphoid organs and crucial for recruitment and compartmentalization of lymphocytes. Both B cells and follicular T helper cells, a special subgroup of CD4 T cells required for B cell activation, follow CXCL13 gradients towards B-T cell contact zones

Serum CXCL13

Elevation of the chemokine CXCL13 in CSF frequently occurs during active and acute CNS inflammatory processes and presumably is associated with B cell‑related immune activation1.

“leaking” of CXCL13 from blood across dysfunctional brain barriers is a possible source1.

CSF CXCL13

CSF CXCL13 is elevated in :

  • Infection of the CNS with B. burgdorferi2
  • Neurosyphilis2
  • Human immunodeficiency virus (HIV)2
  • Aseptic meningitis2
  • CNS lymphoma2

References

1.
Pilz G, Sakic I, Wipfler P, et al. Chemokine CXCL13 in serum, CSF and blood-CSF barrier function: Evidence of compartment restriction. Fluids and barriers of the CNS. 2020;17(1):7. doi:10.1186/s12987-020-0170-5
2.
Roos KL. Neurologic Complications of Lyme Disease. CONTINUUM: Lifelong Learning in Neurology. 2021;27(4):1040-1050. doi:10.1212/CON.0000000000001015

Citation

For attribution, please cite this work as:
Yomogida N, Kerstein C. C-X-C motif ligand 13 (CXCL~13~). https://yomokerst.com/The Archive/Microbiology/Cells/Chemokines/CXCL13_chemokine.html